2010 Fiscal Year Final Research Report
Analysis of the association between the polymorphism of the oxidative stress related gene and prostate carcinogenesis : an autopsy study
| Project/Area Number |
21791524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Osaka City University |
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Principal Investigator |
IGUCHI Taro Osaka City University, 大学院・医学研究科, 講師 (80529206)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 腫瘍学 / 前立腺潜在癌 / 遺伝子多型 / 酸化ストレス |
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| Research Abstract |
The predictive OR of MnSOD AA for significant versus insignificant cancers was 5.04 (sensitivity=0.58; positive predictive value=0.79) in men >70 years old. MnSOD polymorphism is strongly associated with the clinical significance of prostate cancer suggesting that oxidative stress may be involved in the progression of the disease. MnSOD may be a clinically useful marker to predict the potential of progression from clinically insignificant to significant cancers.
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