Analysis of function and the target genes of micro-RNAs in prostate cancer

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Teikyo University
• Principal Investigator: KOJIMA Satoko Teikyo University, 医学部, 准教授 (10345019)
• Co-Investigator(Renkei-kenkyūsha): SEKI Naohiko 千葉大学, 大学院・医学研究院, 准教授 (50345013)
• Project Period (FY): 2009 – 2010
• Keywords: 前立腺癌 / マイクロRNA / アポトーシス / 標的遺伝子解析 / 発現プロファイル

Research Abstract

The mechanism of progression of cancer (PCa) to androgen-independent (AI) stage has not completely known. MicroRNAs (miRNAs) are known to have important roles in cancer development and malignant transformation. It is well known that miR-15a and miR-16-1 functions as tumor suppressor in lymphomas. We previously revealed that miR-15a caused growth inhibition and induced apoptosis in prostate cancer cells. In this study, we identified several miRNAs those were differentially expressed in PCa based on genome-wide miRNA expression signature. Analysis of the target genes may have therapeutic implications and may be exploited for future treatment of advanced PCa.

Research Products

• [Journal Article] Mir-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma : correlation with stage and grade, and comparison with urinary cytology. (2011)
  • Author(s): Yasutoshi Yamada, Hideki Enokida, Satoko Kojima, Kazumori Kawakami, Takeshi Chiyomaru, Shuichi Tatarano, Hirofumi Yoshino, Kazuya Kawahara, Kenryu Nishiyama, Naohiko Seki, Masayuki Nakagawa.
  • Journal Title: Cancer Sci 102(3) Pages: 522-529
  • Peer Reviewed
• [Journal Article] Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1. (2011)
  • Author(s): Miki Fuse, Nijiro Nohata, Satoko Kojima, Shinichi Sakamoto, Takeshi Chiyomaru, Kazumori Kawakami, Hideki Enokida, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki.
  • Journal Title: Int.J.Oncol. 38 Pages: 1093-1011
  • Peer Reviewed
• [Journal Article] Implications of IGF-I for prostate cancer therapies. (2009)
  • Author(s): Satoko Kojima, Masahiko Inahara, Yoshihiro Suzuki, Tomohiko Ichikawa, Yuzo Furuya
  • Journal Title: Int.J.Urol. 16(2) Pages: 161-167
  • Peer Reviewed
• [Presentation] 前立腺癌におけるmiR-200 familyおよびmiR-205の機能解析 (2010)
  • Author(s): 小島聡子、榎田英樹、千代丸剛、中川昌之、稲原昌彦、納谷幸男、関直彦
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 20100922-20100924
• [Presentation] 進行前立腺癌におけるmicroRNAのプロファイル解析 (2010)
  • Author(s): 小島聡子、榎田英樹、千代丸剛、稲原昌彦、中川昌之、納谷幸男、関直彦
  • Organizer: 第19回泌尿器分子・細胞研究会
  • Place of Presentation: 鹿児島
  • Year and Date: 20100219-20100220
• [Presentation] 進行前立腺癌におけるmicroRNAの発現解析 (2009)
  • Author(s): 小島聡子、有馬雅史、榎田英樹、千代丸剛、中川昌之、稲原昌彦、関直彦
  • Organizer: 第68回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20091001-20091003
• [Presentation] (2009)
  • Author(s): Satoko Kojima, Ryoko Watanabe, Jun Tsukada, Yuzo Furuya, Naohiko Seki.
  • Organizer: The 100^<th> AUA annual meeting MiR-15a functions as a tumor suppressor for prostate cancer by targeting multiple oncogenes.
  • Place of Presentation: Chicago, Illinois, USA.
  • Year and Date: 20090425-20090430
• [Presentation] MiR-15a functions as a tumor suppressor for prostate cancer by targeting multiple oncogenes. (2009)
  • Author(s): Satoko Kojima, Ryoko Watanabe, Jun Tsukada, Yuzo Furuya, Naohiko Seki
  • Organizer: EUA The 24^<th> annual congress of European association of urology, 17-21 march 2009 Stockholm, Sweden Abstract 777.
  • Place of Presentation: Stockholm, Sweden.
  • Year and Date: 20090317-20090321
• [Remarks] ホームページ等