2011 Fiscal Year Final Research Report
Functions of endometrial and circulating NK cells for achievement and maintenance of pregnancy
| Project/Area Number |
21791536
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hirosaki University |
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Principal Investigator |
FUKUI Atsushi 弘前大学, 医学部・附属病院, 講師 (00321969)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生殖医学 / NK細胞 / Natural Cytotoxicity Receptor / サイトカイン |
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| Research Abstract |
I evaluated the function of NK cells for achievement and maintenance of pregnancy using pregnant and non-pregnant peripheral blood NK cells and non-pregnant endometrial NK cells. The abnormal expression of natural cytotoxicity receptors (NCRs), especially NKp46 on NK cell is associated with reproductive failures. The abnormal cytokines production by NK cells exists in reproductive failures. There is a direct correlation between the expression of NKp46 on NK cell and cytokines production by NK cells.
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[Journal Article] Changes of NK cells in preeclampsia2012
Author(s)
Fukui A, Yokota M, Funamizu A, Nakamua R, Fukuhara R, Yamada K, Kimura H, Fukuyama A, Kamoi M, Tanaka K, Mizunuma H
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Journal Title
American journal of reproductive immunology
Volume: 67
Pages: 278-286
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[Journal Article] Fluctuation of peripheral blood T, B, and NK cells during a menstrual cycle of normal healthy women2010
Author(s)
Lee S, Kim J, Jang B, Hur S, Jung U, Kil K, Na B, Lee M, Choi Y, Fukui A, Gilman-Sachs A, Kwak-Kim JY
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Journal Title
J Immunol
Volume: 185
Pages: 756-762
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