2011 Fiscal Year Final Research Report
Expression of miRNA in human epithelial ovarian cancer
| Project/Area Number |
21791537
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
AKAHIRA Junichi 東北大学, 大学院・医学系研究科, 非常勤講師 (90359505)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 婦人科腫瘍学 |
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| Research Abstract |
miR-34b was found to have promoter hypermethylation, which when reversed, restored miR-34b expression in the endometrial serous cancer (ESC)cell lines treated with 5-aza-2' deoxycytidine. miR-34b transfection inhibited ESC cell growth, migration and most notably invasion. These effects were mediated by miR-34b target gene, the mesenchymal epithelial transition factor (MET). The expression of MET was reduced following the restoration of miR-34b in ESC cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of endometrial cancer.
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Research Products
(10 results)
