2010 Fiscal Year Final Research Report
The new development of ovulation inductor associated with the expression of PTEN in human granulosa cells.
| Project/Area Number |
21791549
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
GOTO Maki Nagoya University, 医学部附属病院, 助教 (90378125)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 卵胞発育 / ヒト顆粒膜細胞 / PTEN / インスリン抵抗性 / 多嚢胞性卵巣症候群 |
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| Research Abstract |
Granulosa cells proliferate and then undergo differentiation ; an inverse relationship between these processes is observed during terminal follicular growth. But this proliferation/differentiation transition is not fully understood. We show that PTEN was induced with hCG treatment in human luteinized granulosa cells. Pretreatment with hCG attenuated IGF-1-induced phosphorylation of AKT and cell proliferation. Furthermore, we assess the induction of PTEN expression with insulin treatment and effects of PTEN on IGF-I-induced granulosa cell proliferation as well as the correlation of PTEN levels with the concentration of insulin in follicular fluid in PCOS and non-PCOS patients.
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[Journal Article] Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles.2010
Author(s)
Takikawa S, Iwase A, Goto M, Harata T, Umezu T, Nakahara T, Kobayashi H, Suzuki K, Manabe S, Kikkawa F.
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Journal Title
Gynecol Endocrinol 26(7)
Pages: 494-499
Peer Reviewed
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[Remarks] ホームページ等
