2010 Fiscal Year Final Research Report
Development of a therapeutic agent against ovarian clear cell carcinoma based on chemogenomics.
Project/Area Number |
21791551
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
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Research Institution | Kyoto University |
Principal Investigator |
MATSUMURA Noriomi Kyoto University, 医学研究科, 助教 (20452336)
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Project Period (FY) |
2009 – 2010
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Keywords | 婦人科腫瘍学 |
Research Abstract |
Microarray analysis of ovarian clear cell carcinoma revealed similarity with renal cell carcinoma and activated Ras activity. Sorafenib, a multi-kinase inhibitor effective against renal cell carcinoma, showed prominent anti-tumor effect against ovarian clear cell carcinoma in an animal study. Sorafenib was administered to a chemoresistant recurrent ovarian clear cell carcinoma with the approval of Medical Ethics Committee in Kyoto University.
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[Journal Article] The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.2011
Author(s)
Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I.
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Journal Title
Int J Cancer.(Epub ahead of print)
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[Journal Article] Distinguishing primary from secondary mucinous ovarian tumors : an algorithm using the novel marker DPEP1.2011
Author(s)
Okamoto T, Matsumura N, Mandai M, Oura T, Yamanishi Y, Horiuchi A, Hamanishi J, Baba T, Koshiyama M, Shiozawa T, Konishi I.
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Journal Title
Mod Pathol. 24(2)
Pages: 267-276
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[Journal Article] GPR54 is a target for suppression of metastasis in endometrial cancer.2011
Author(s)
Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.
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Journal Title
Mol Cancer Ther. 10(4)
Pages: 580-590
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[Journal Article] Oct4 expression in immature teratoma of the ovary : relevance to histologic grade and degree of differentiation.2010
Author(s)
Abiko K, Mandai M, Hamanishi J, Matsumura N, Baba T, Horiuchi A, Mikami Y, Yoshioka S, Wakasa T, Shiozawa T, Konishi I.
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Journal Title
Am J Surg Pathol. 34(12)
Pages: 1842-1828
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[Journal Article] Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.2010
Author(s)
Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I.
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Journal Title
Cancer Sci. 101(12)
Pages: 2658-2663
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[Journal Article] Targeting slow-proliferating ovarian cancer cells.2010
Author(s)
Kondoh E, Mori S, Yamaguchi K, Baba T, Matsumura N, Cory Barnett J, Whitaker RS, Konishi I, Fujii S, Berchuck A, Murphy SK.
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Journal Title
Int J Cancer. 126(10)
Pages: 2448-2456
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[Presentation] Oral presentation "Genomewide methylation analyses reveal a prominent role of HNF1 network genes, via hypomethylation, in ovarian clear cell carcinoma"2011
Author(s)
N.Matsumura, M.Mandai, T.Okamoto, K.Yamaguchi, T.Oura, T.Baba, S.Mori, S.Murphy, I.Konishi
Organizer
The 42 nd Annual Meeting of the Society of Gynecologic Oncologists
Place of Presentation
Florida
Year and Date
2011-03-06
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