2011 Fiscal Year Final Research Report
The study of Prevention and Solution of Hypersensitivity Reaction in Administration of Paclitaxel
| Project/Area Number |
21791563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WAKE Norio 九州大学, 病院産科婦人科, 教授 (50158606)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 過敏症反応 / パクリタキセル |
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| Research Abstract |
Pacl i t axel i s an i mpirt ant agent for gynecol ogi c nal i gnanci es, but sonetines this agent provokes hypersensitive reaction In the aninnal experinent, beyritrasbutter, such as subst abce Pand CGRP, rekated to HSR of TXL, and it proved that blood concent ration of Substance P by TXL medi cation or CGRP was measured by blood collecting 5 minutes before TXL medi cation and after medication, and relation with HSR development of sympt ons was considered. Ait bough the serumconcent ration of Substance Por CGRP acceptons was considered. Aothough the serumconcent ration of Substance Por CGRP accepted the tendency to go up, in the HSR eevelopment of symptons group, the significant difference did not accept
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