2010 Fiscal Year Final Research Report
Characteristic changes in endothelial function by administration of NO synthase inhibitor during placental formation
| Project/Area Number |
21791569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya City University |
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Principal Investigator |
YAMAMOTO Tamao Nagoya City University, 大学院・医学研究科, 研究員 (20405210)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 妊娠高血圧症候群 / 血管内皮機能障害 / 一酸化窒素 / 活性酸素 |
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| Research Abstract |
It is found that administration of the NOS inhibitor L-NAME at early pregnancy developed hypertension in rat. Blood pressure was increasing, while birth body weight was smaller in L-NAME-treated rats than in saline-treated rats. Acetylcholine (ACh)-induced endothelial nitric oxide (NO) production in uterine artery was higher, although ACh-induced reactive oxygen species production was similar in L-NAME-treated rats. It is suggested that the increased endothelial NO production in uterine artery by administration of L-NAME may protect the development of hypertension in endothelium.
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