2010 Fiscal Year Final Research Report
Study on the chromosome aberration and infertility of an egg.
| Project/Area Number |
21791570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka City University |
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Principal Investigator |
YOSHIDA Kayo Osaka City University, 大学院・医学研究科, 准教授 (30311921)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 遺伝子 / 細胞・組織 / 発現制御 / 発生・分化 / 放射線 |
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| Research Abstract |
It is important to analyze the mechanisms of chromosome behavior in meiosis in mammals for chromosome aberrations in fetus. It will also contribute to diagnosis and treatment. We found that histone H2AX gene was involved in repair of DNA damages.We analyzed the effect of DNA damages by X-irradiation to early development of embryos. Furthermore, we made histone H2AX knock-out mouse and analyzed its effect after DNA damages.
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