Innovation of prognosis and therapeutic method for complications in pregnancy using adipokine technology

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791571
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Nara Medical University
• Principal Investigator: NARUSE Katsuhiko Nara Medical University, 医学部, 助教 (70453165)
• Project Period (FY): 2009 – 2010
• Keywords: 脂肪細胞

Research Abstract

Cytokines derived from adipocyte (adipocytokine), mainly adiponectin, were studied to clarify the effects of adipocyte on trophoblasts in normal and complicated pregnancy. The effect of free fatty acid on secretion of adiponectin was suggested in pregnancy induced hypertension. Additionally, coordinal alteration of high molecular weight adiponectin and chemokine in the course of normal pregnancy were clarified.

Research Products

• [Journal Article] Effect of tumour necrosis factor-a in combination with interferon-Y on first trimester extravilous trophoblast invasion. (2011)
  • Author(s): Otun HA, Lash GE, Innes BA, Bulmer JN, Naruse K, Hannon T, Searle RF, Robson SC.
  • Journal Title: J Reprod Immunol 88 Pages: 1-11
• [Journal Article] Fatal Factors of Clinical Manifestations and Laboratory Testing in Patients with Amniotic Fluid Embolism. (2010)
  • Author(s): Oi H, Naruse K, Noguchi T, Sado T, Kimura S, Kanayama N, Terao T, Kobayashi H.
  • Journal Title: Gynecol Obstet Invest. 70 Pages: 138-144
• [Journal Article] Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy. (2010)
  • Author(s): Naruse K, Innes BA, Bulmer JN, Robson SC, Searle RF, Lash GE.
  • Journal Title: J Reprod Immunol 86 Pages: 148-150
• [Journal Article] 妊娠とアディポネクチン～正常妊婦の血中濃度推移と脂肪細胞における基礎的検討～ (2010)
  • Author(s): 成瀬勝彦
  • Journal Title: 糟尿病と妊振 10 Pages: 32-35
• [Journal Article] アディポネクチンを指標とした妊娠糖尿病および妊娠高血圧症候群の早期予知と介入効果～インスリン抵抗性周産期疾患の減少を目指して～ (2010)
  • Author(s): 成瀬勝彦, 小林浩, 佐道俊幸, 坂田麻理子, 吉田昭三, 大野木輝
  • Journal Title: 第41回「医学研究助成」研究報告集(三井生命厚生事業団) 41 Pages: 7-9
• [Journal Article] Secretion of Angiogenic Growth Factors by Vinous Cytotrophoblast and Extravillous Trophoblast in Early Human Pregnancy. (2010)
  • Author(s): Lash GE, Naruse K, Innes BA, Robson SC, Searle RF, Bulmer JN.
  • Journal Title: Placenta 31 Pages: 545-548
• [Journal Article] The urokinase plasminogen activator (uPA) system in uterine natural killer cells in the placental bed during early pregnancy. (2009)
  • Author(s): Naruse K, Lash GE, Bulmer JN, Innes BA, Otun HA, Searle RF, Robson SC.
  • Journal Title: Placenta 30 Pages: 398-404
• [Journal Article] Oxytocin Hypersensitivity in Pregnant P-LAP Deficient Mice. (2009)
  • Author(s): Ishii M, Naruse K, Hattori A, Tsujimoto M, Ishiura S, Numaguchi Y, Murohara T, Kobayashi H, Mizutani S.
  • Journal Title: Life Sci. 84 Pages: 668-672
• [Presentation] Correlation of free fatty acid and adiponectin in hypertensive pregnancy : key molecules for homeostatic inflammatory linkage. (2010)
  • Author(s): Naruse K, Onogi A, Sado T, Noguchi T, Komeda S, Koyama E, Nishioka K, Kitanaka T, Oi H, Kobayashi H.
  • Organizer: 17th World congress of the International Society for the Study of Hypertension (ISSHP).
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2010-10-05
• [Presentation] Invasive activities of primary extravillous trophoblast via altered activity in low oxygen condition. (2010)
  • Author(s): Naruse K, Onogi A, Noguchi T, Sado T, Kitanaka T, Oi H, Kobayashi H.
  • Organizer: XI International Congress of Reproductive Immunology (ICRI).
  • Place of Presentation: Palm Cove Resort, Cairns, Australia
  • Year and Date: 2010-08-15
• [Presentation] Adipocyte-derived cytokines alteration for systemic inflammation in hypertensive pregnancy : Studies into matemal serum and adipocyte cell line. (2009)
  • Author(s): Naruse K, Onogi A, Sado T, Shigetomi H, Komeda S, Koyama E, Kitanaka T, Oi H, Kobayashi H.
  • Organizer: 3rd SGI International Summit 2009.
  • Place of Presentation: Sendai, Japan.
  • Year and Date: 2009-11-12
• [Presentation] Effects of Adiponectin in Differentiation, Invasion and Migration of Human Trophoblastic Cells. (2009)
  • Author(s): Onogi A, Naruse K, Shigetomi H, Yoshizawa Y, Noguchi H, Sado T, Kitanaka T, Oi H, Kobayashi H.
  • Organizer: 15th World Congress of International Federation of Placenta Association (IFPA).
  • Place of Presentation: Adelaide, Austraria
  • Year and Date: 2009-10-06
• [Presentation] Adipocyte-derived cytokines in hypertensive pregnancy : A trigger for systemic inflammation. (2009)
  • Author(s): Naruse K, Onogi A, Sado T, Shigetomi H, Yoshida S, Kitanaka T, Oi H, Kobayashi H.
  • Organizer: European branch of International Society for Study of Hypertension in Pregnancy (ESSHP).
  • Place of Presentation: Oxford, England.
  • Year and Date: 2009-09-10