Antitumor effect of siRNA on endometrial cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791573
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: YANOKURA Megumi 慶應義塾大学, 医学部, 特任助教 (20433732)
• Project Period (FY): 2009 – 2011
• Keywords: siRNA / 子宮体癌

Research Abstract

Tumor development occurred 3 weeks after transplantation of HEC-1B cells in nude mice. Drugs were administered on that day and thereafter. The tumor diameter significantly decreased in mice treated with paclitaxel+Aurora-A siRNA compared with the results for other treatments(P<0. 05). The GFP fluorescence signal also markedly decreased after treatment with paclitaxel+Aurora-A siRNA.
Aurora-A siRNA may have the potential to increase the sensitivity of endometrial tumors to treatment with paclitaxel.

Research Products

• [Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA a nd microRNA by Epigenetics (2012)
  • Author(s): Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
  • Journal Title: Biochemistry Research International Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Epigenetics and genetics in endometrial cancer : new carcinogenic mechanisms and relationship with clinical practice (2012)
  • Author(s): Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
  • Journal Title: Epigenomics Volume: 4 Pages: 147-162
  • Peer Reviewed