2010 Fiscal Year Final Research Report
Replication of HIV in immortalized human trophoblasts
| Project/Area Number |
21791575
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nihon University |
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Principal Investigator |
IZUMI Yasuyuki Nihon University, 医学部, 研究員 (50459872)
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| Project Period (FY) |
2009 – 2010
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| Keywords | HIV / 垂直感染 / 胎盤絨毛 / Trophoblast / LPS |
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| Research Abstract |
HIV replicates in immortalized human first trimester trophoblast cell line in a CD4 independent manner. The HIV replication was up-regulated by lipopolysaccharide. These results suggested molecular basis of increased risk of maternal fetal infection by local infection by Gram-negative bacteria.
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Research Products
(1 results)
