2010 Fiscal Year Final Research Report
Regulation mechanism and function of Latent Membrane protein of Epstein-Barr Virus in nasal NK/T cell lymphoma cells.
| Project/Area Number |
21791583
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
MIKI Takahara Asahikawa Medical College, 医学部, 助教 (50322904)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 鼻性NK / T細胞リンパ腫 / Epstein-Barr virus / LMP1(latent membrane protein 1) / IP-10(Interferon gamma-induced protein-10) / monocytes |
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| Research Abstract |
Nasal NK/T-cell lymphoma is EBV-related malignancy, and has a poor prognosis. We have already shown that an expression of LMP-1, EBV-originated oncoprotein, was enhanced by cytokines such as IL-2, 10, and 15 in nasal NK/T-cell lymphoma cell lines. In this study, we found that chemokine IP-10 (Interferon gamma-induced protein-10) was induced by LMP-1, and IP-10 enhanced invasive potential of the cells in autocrine manner. Moreover, we revealed that monocytes attracted by IP-10 enhanced proliferation and LMP-1 expression of the cells by cell-contact manner via membrane-bound IL-15. Therefore, LMP-1 enhanced the proliferating and invasive potential of the cells through IP-10 or monocytes.
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