2011 Fiscal Year Final Research Report
Study of the middle ear reconstruction with bone morphogenetic protein
| Project/Area Number |
21791594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
SUGIMOTO Akira 千葉大学, 大学院・医学研究院, 助教 (50436432)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 側頭骨再生 / 骨形成蛋白(BMP) / マイクロCT / 鼓室形成術 / 乳突削開術 / 含気化 |
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| Research Abstract |
There is currently no established method for reconstructing temporal bone defects after tympanoplasty or mastoidectomy. Bone tissue reconstruction using tissue engineering techniques is currently receiving attention. This study demonstrated that micro CT devices for animals are very effective for observing bone regeneration. Moreover, of the bone morphogenetic proteins that are capable of forming normal bone, BMP-2 was more efficient at bone formation than PDGF and β-TCP. BMP-2 was shown to have a strong ability to reconstruct bone tissue in temporal bone, and construction of a pneumatic space was confirmed for the first time.
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