2010 Fiscal Year Final Research Report
Molecular biological analyses of age-related olfactory dysfunction
| Project/Area Number |
21791598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KONDO Kenji The University of Tokyo, 医学部附属病院, 講師 (40334370)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 嗅神経細胞 / 加齢変化 / 再生 |
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| Research Abstract |
We investigated the pathophysiology underlying age-related progression in degeneration of the olfactory mucosa using various mouse models and immunohistochemical methods. The analyses of mechimazole-induced neuroepithelial degeneration revealed that although mouse olfactory neuroepithelium retained the capacity to reconstitute neuroepithelium as well as innervate the olfactory bulb even in 16-month-old mice, the final anatomical recovery was less complete in 16-month-old mice compared with the younger mice. Cell kinetics analyses of the reconstituting neuroepithelium suggested that such a age-related decline in the capacity to reconstitute neuroepithelium is associated with its age-related decrease in proliferative activity after the neuroepithelial injury rather than changes in the process of neuronal differentiation.
We also prepared ovariectomized mice and bled estrogen receptor beta-knockout mice to examine the involvement of estrogen in the homeostasis of olfactory mucosa.
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[Journal Article] Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: cell proliferation, neuronal differentiation and cell death.2010
Author(s)
Kondo K, Suzukawa K, Sakamoto T, Watanabe K, Kanaya K, Ushio M, Yamaguchi T, Nibu K, Kaga K, Yamasoba T
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Journal Title
J Comp Neurol 518
Pages: 1962-1975
Peer Reviewed
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