2011 Fiscal Year Final Research Report
The immunosuppressive role of MDSC in microenvironment of head and neck cancer
| Project/Area Number |
21791606
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 頭頸部外科学 |
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| Research Abstract |
Myeloid-derived suppressor cells(MDSC) represent a heterogeneous population and have the potential to suppress immuneresponses via diverse mechanisms. MDSC was identified by the markers HLA-DR in theperipheral blood from cancer patients. In this study, we investigated the proportions and characteristics of CD14+HLA-DR_cells in patients with squamous cell carcinoma of the head and neck(SCCHN). The sorted CD14+HLA-DR_cells were able to suppress effectively both the proliferation and IFN-c production of anti-CD28 stimulated T cells, suggesting that CD14+HLA-DR_cells act as potent immunosuppressive cells and particularly contribute to tumor escape from the host immune system in patients with SCCHN.
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