2010 Fiscal Year Final Research Report
Research in the metabolic dynamics of the molecular component of the tip link, essential structure for hearing reception
| Project/Area Number |
21791634
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SAKAGUCHI Hirofumi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (00515223)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 聴覚 / 内耳 / 蝸牛 / 有毛細胞 / tip link / カドヘリン / cadherin 23 / protocadherin |
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| Research Abstract |
In the current study, we observed regeneration process of tip link, a key player for the mechanotransduction in inner ear hair cells, and showed its possible spontaneous regeneration in mammal, as same as previously shown in avian. Our data also suggested the difference in the regeneration potential between inner and outer hair cells. Moreover, we demonstrated that the morphology of the apical surface in outer hair cells achieves its specific shape during the period of the tip link maturation.
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