2010 Fiscal Year Final Research Report
Analysis of pneumococcal surface protein and development of pneumococcal vaccine inhibiting colonization in the upper respiratory tract
| Project/Area Number |
21791639
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
SAKAI Akihiro Wakayama Medical University, 医学部, 博士研究員 (50423950)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 耳科学 |
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| Research Abstract |
We analyzed the pneumococcal surface proteins of pneumococcal strains from children with otitis media by PCR assay. Recombinant pneumococcal surface proteins were made by TA cloning method. Pneumococcal colonization in the nasopharynx was prevented by intranasal immunization with recombinant pneumococcal surface protein in the mouse model. Cross-protective-reactivity between pneumococcal surface protein families were shown in the systemic infection model. Intranasal immunization with pneumococcal surface protein is important about the development of novel vaccines in the near future.
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