2010 Fiscal Year Final Research Report
osteoclasts regulate morphology of auditory ossicles and maintaining hearing function
| Project/Area Number |
21791643
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
KANZAKI Sho Keio University, 医学部, 講師 (50286556)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 耳小骨 / 破骨細胞 / 耳硬化症 / 大理石病 / 難聴 |
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| Research Abstract |
We analyzed hearing function and morphological features of auditory ossicles in osteopetrotic mice, which lack osteoclasts because of the deficiency of either cytokine RANKL or transcription factor c-Fos. Osteopetrotic mice showed severe hearing loss and a smaller volume of the tympanic cavity but had larger auditory ossicles compared with controls. Unexpected contact of ossicles to the otic capsule causes hearing loss.
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