2010 Fiscal Year Final Research Report
osteoclasts regulate morphology of auditory ossicles and maintaining hearing function
Project/Area Number |
21791643
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Otorhinolaryngology
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Research Institution | Keio University |
Principal Investigator |
KANZAKI Sho Keio University, 医学部, 講師 (50286556)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 耳小骨 / 破骨細胞 / 耳硬化症 / 大理石病 / 難聴 |
Research Abstract |
We analyzed hearing function and morphological features of auditory ossicles in osteopetrotic mice, which lack osteoclasts because of the deficiency of either cytokine RANKL or transcription factor c-Fos. Osteopetrotic mice showed severe hearing loss and a smaller volume of the tympanic cavity but had larger auditory ossicles compared with controls. Unexpected contact of ossicles to the otic capsule causes hearing loss.
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Research Products
(4 results)