2010 Fiscal Year Final Research Report
The study for the expression and the role of thermo-sensitive TRP channels.
| Project/Area Number |
21791658
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
SHIBATA Minori University of Occupational and Environmental Health, Japan, 医学部, 助教 (90512187)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 鼻科学 / 温度センサー / TRPチャネル / ヒト |
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| Research Abstract |
The relationship between the nose and thermo-sensitive TRP channels using fluorescent immunohistochemistry and confocal laser scan microscope was examined. Specific distribution of TRPV1 and TRPM8 was found in the human inferior turbinate. Moreover, co-localization of the inflammatory mediators SP, CGRP, a nerve marker PGP9.5 with TRPV1 and M8 were examined.
These findings suggest the possibility of a new mechanism to regulate the nasal conditions without autonomic nerve reflex.
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