2010 Fiscal Year Final Research Report
Unfolded protein response in age related macular degeneration and retinal degeneration.
| Project/Area Number |
21791677
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
KACHI Shu Nagoya University, 医学部附属病院, 講師 (30345904)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小胞体ストレス / アミロイドβ / アポトーシス / カスパーゼ12 / カスパーゼ4 / GADD153 / CHOP / 4-フェニル酪酸 / ARPE-19 |
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| Research Abstract |
It is reported that amyloid beta stimulates the vascular endothelial growth factor (VEGF) expression from the retinal pigment epithelium (RPE) cells. We found that amyloid beta also increases the expression of the unfolded protein response (UPR) markers. These increases of VEGF and UPR were down-regulated by addition of 4-phenylbutyric acid (PBA), UPR inhibitor, to the medium.
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