2011 Fiscal Year Final Research Report
Development of neuroprotective therapy for glaucoma with anti-Alzheimer' s agent using rat model
| Project/Area Number |
21791682
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
MIKI Atsuya 大阪大学, 医学系・研究科, 助教 (30437404)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 眼細胞生物学 |
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| Research Abstract |
By ligation of rat episcleral veins, elevation of intraocular pressure(IOP) from 13. 2mmHg preoperatively to 19. 4mmHg at 5 weeks after operation after ligation of 2 veins, and from 14. 6mmHg to 20. 7 mmHg after ligation of 3 veins, was observed. By cauterizing rat episcleral veins, mean IOP was 10. 3 mmHg preoperatively, and 10. 0 mmHg at 1 week after operation. We did not observe any significant change in IOP after anterior chamber angle photocoagulation or after intravitreal injection of steroids.
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