2011 Fiscal Year Final Research Report
The regulation of the expression of membrane-associated mucins in the ocular surface
| Project/Area Number |
21791683
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Toho University |
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Principal Investigator |
HORI Yuichi 東邦大学, 医学部, 准教授 (70379171)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ドライアイ / ムチン / オキュラーサーフェス / 膜型ムチン |
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| Research Abstract |
The Ocular Surface Epithelia express membrane-associated mucins, MUC1, MUC4, and MUC16, which play an important role of the ocular surface barrier function. In our study, we reported that contact lens solutions(MPSs : Multi Purpose Solutions) containing boric acid significantly reduced gene expressions of MUC1, MUC4 and MUC16mRNA in the human corneal epithelial cells. Among ingredients, 0.1% boric acid significantly reduced gene expressions of MUC1and MUC16.Furthermore, we observed that preservative agent of eye drop, benzalkonium chloride(BAC), reduced the expression of MUC16mRNA and damaged the mucin barrier function in the human conjunctival epithelial cells. We believe that our results can help us to figure out the mechanism of the drug-induced keratopathy and to develop the useful eye drops with fewer side effects.
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Research Products
(20 results)
