2010 Fiscal Year Final Research Report
The analysis of mechanism for corneal ulceration and the development of new drugs
| Project/Area Number |
21791687
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KIMURA Kazuhiro Yamaguchi University, 医学部付属病院, 講師 (60335255)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 角膜潰瘍 / コラーゲン分解 / 病原微生物 |
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| Research Abstract |
Corneal ulceration results from the destruction of collagen fibrils in the stroma. Histological observations have revealed that corneal keratocytes, fibroblasts and infiltrated leukocytes are present at corneal tissue affected by ulceration. Corneal fibroblasts have an important role in the formation of corneal ulceration.In responses to lipopolysaccharide (LPS), polyinosinic-polycytidylic acid [poly(I:C)], and zymosan as surrogates for bacteria, viruses, and fungi, the cells produces various cytokines, chemokines and matrix metalloproteinases.
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