2011 Fiscal Year Final Research Report
Search of the prophylaxis of the cornea I endothelium disorder by the TGFβ signal inhibition using the gene introduction
| Project/Area Number |
21791705
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 角膜内皮 / 角膜上皮 / 角膜実質 / 創傷治癒 |
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| Research Abstract |
Ahealthy endothelium is essential for the maintenance of transparency of the cornea. An alkali burn in the cornea is a clinically serious condition because it damages not only the epithelium and stroma but also the endothelium. During healing after an alkali burn, the fibrous structure is formed in the endothelial layer beneath Descemet' smembrane. Formation of such fibrous structure impairs the physiologic function of the endothelium to maintain transparency. Blocking Smad signal effectively suppresses injury-induced endothelial-mesenchymal transition and fibrogenic reaction by corneal endothelium without impairing repair of wound defect. Strategies that block Smad may be useful for prevension and treatment of fibrogenic disorders in the corneal endothelium.
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