Regeneration of Interstitial cells of Cajal for gastrointestinal motility disorder.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21791735
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: Keio University
• Principal Investigator: MORI Masaharu 慶應義塾大学, 医学部, 助教 (00445389)
• Project Period (FY): 2009 – 2011
• Keywords: カハール / 腸管運動 / 再生 / 間葉系幹細胞 / 移植

Research Abstract

Interstitial cells of Cajal(ICC) that work as pacemaker cells in gut play important roles in autonomic gut motility as well as intestinal smooth muscles and nerves. It has been reported that the number of ICC is decreased in various conditions such as Hirschsprung's disease, diabetes mellitus, and imflammatory bowel disease. It is expected that regeneration of ICC improve gut motility in such conditions. In this study, we succeeded to differentiate murine bone marrow mesenchymal stem cells into cells that were morphologically compatible with ICC in either optical and electron microscopy.

Research Products

• [Presentation] Mesenchymal Stem Cell tran splantation from murine bone marro wdifferentiated into ICC marker posi tive cells (2012)
  • Author(s): 森昌玄
  • Organizer: The 3^<rd> International Sym posium on the Development of the E nteric Nervous System : Cells, Signals and Genes
  • Place of Presentation: 香港
  • Year and Date: 2012-03-26
• [Presentation] 間葉系幹細胞を用いたカハール細胞再生の試み (2011)
  • Author(s): 森昌玄
  • Organizer: 第48回日本小児外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-20
• [Presentation] 間葉系幹細胞によるカハール細胞再生医療の試み (2011)
  • Author(s): 森昌玄
  • Organizer: 第41回小児消化管機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-26