2011 Fiscal Year Final Research Report
Role of P75NTR in peripheral nerve regeneration
| Project/Area Number |
21791743
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
HATA Yuki 大阪大学, 医学部附属病院, 医員 (10351058)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 末梢神経再生 / p75NTR / シュワン細胞 / 創傷治癒 / 線維芽細胞 |
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| Research Abstract |
Double transgenic mice without P75NTR and with GFP expression in S-100 protein was successfully created. We invented the way to visualize myelin sheath regeneration by peripheral nerve transplantation. In addition, we proved that lack of p75 Low Affinity Nerve Growth Factor Receptor(p75NTR) impairs the migration, proliferation and the differentiation to miofibroblasts in fibroblasts of mice.
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