2013 Fiscal Year Final Research Report
Mechanism identification of fat graft regeneration and angiogenesis with adipose-derived stem cells.
| Project/Area Number |
21791760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Research Collaborator |
OGAWA Takeshi 関西医科大学, 医学部, 研究員 (80739269)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Keywords | 幹細胞 / 脂肪 / 血管新生 |
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| Research Abstract |
In the present study, we have demonstrated that angiogenic potential plays an important role in tissue regeneration and stem cell engraftment and that adipose-derived stem cells, in particular, has a property toprodece many growth factors with angiogenic action, such as vascular endothelial growth factor, Fibroblast growth factor-2, and hepatocyte growth factor, which is enhanced via Hypoxia inducible factor-alpha expression under hypoxia conditions. As local blood flow and angiogenesis plays a crucial role for tissue engraftment and regeneration, it has been clarified that stem cell plays a key role in tissue regeneration using adipose-derived stem cell.
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