2010 Fiscal Year Final Research Report
Examination of the efficacy of high-dose immunoglobulin in a rat model of sepsis
| Project/Area Number |
21791776
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 集中治療学 |
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| Research Abstract |
Treatment with immunoglobulin significantly improved survival rate at postoperative day 7 (73% in the high-dose group vs. 33% in the control group ; p=0.037). The serum creatinine and blood urea nitrogen levels were significantly lower in the high-dose group than in the other groups. The serum HMGB1 level had increased at 4 hours postoperatively in the control group (10.2±3.3 ng/ml) and low-dose group (10.3±4.0 ng/ml), but it was significantly reduced in the high-dose group (4.2±0.8 ng/ml) compared to the control group (p=0.03). Our results suggest that high-dose immunoglobulin therapy might improve the pulmonary pathology and overall survival rate in sepsis by inhibiting the inflammation.
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