2010 Fiscal Year Final Research Report
The study of regulation of bone metabolism and hematopoietic stem cell niche by steroid hormone and these target factors
| Project/Area Number |
21791787
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIYAMA Shinji Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (60314754)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 骨代謝 / エストロゲン / 幹細胞ニッチ |
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| Research Abstract |
To clarify the regulation of mechanism of bone metabolism and hematopoietic stem cell niche by estrogen, we used the medullary bone formation model of estrogen-treated male Japanese quails. Medullary bone remodeling was under the control of OPG/RANKL/RANK system. During medullary bone formation period, the population of bone marrow cells shifts from undifferentiated cells to osteoclast precursor cells and osteoblasts on the medullary bone act as a niche cells. These results suggest that estrogen may be related to regulate of hematopoietic stem cell niche.
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