2010 Fiscal Year Final Research Report
The relationship between functional regulation of TRPV4 in oral epithelium and food preference
| Project/Area Number |
21791792
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
王 冰 Kyushu University, 歯学研究院, 学術研究員 (20452716)
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| Project Period (FY) |
2009 – 2010
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| Keywords | TRPV4 / ラット / 口腔粘膜上皮 |
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| Research Abstract |
I hypothesized that oral epithelial cells have perception of multi-stimuli in the oral environment. So I investigated the expression of TRPV4 channels, which were known as sensors for warm temperature, mechanical and chemical stimuli, in rat. T identified TRPV4 expression at mRNA and protein level. To investigate it's functional characters, I took advantage of electrophysiological and Ca2+imaging methods. Using TRPV4 activators and inhibitors, I observed TRPV4 induced currents and Ca2+ mobility.
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