2010 Fiscal Year Final Research Report
Developmental mechanisms regulating tooth succession and accession in the house shrew (Suncus murinus)
| Project/Area Number |
21791794
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
YAMANAKA Atsushi Kagoshima University, 医歯学総合研究科, 准教授 (80343367)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 歯の発生 / 歯の交換 / 二生歯性 / 乳歯 / 永久歯 / Shh / スンクス |
|---|
| Research Abstract |
The diphyodont tooth replacement in mammals is characterized by a single replacement of a deciduous dentition by a permanent dentition. Because the mouse never replaces its teeth, this study used the house shrew, Suncus murinus, as a model to investigate the control of the diphyodont replacement by successions and accessions of teeth. The developmental sequence of tooth germs in the house shrew indicates that two adjacent tooth germs do not develop simultaneously, but with a constant time lag. We suggest that this mode of tooth succession and accession can be explained by a sequential inhibitory cascade model in which the timing of initiation and the spacing of tooth development are determined by the inhibition from developmentally preceding adjacent tooth germs.
|
Research Products
(7 results)
