2010 Fiscal Year Final Research Report
Molecular biological studies on the effect of Candida albicans on invasion of host cells by pe riodontopathic bacteria.
| Project/Area Number |
21791795
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
TAMAI Riyoko Ohu University, 歯学部, 助教 (90367566)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯周病原性細菌 / Porphyromonas gingivalis / 侵入 / Candida albicans / 歯周病 / 混合感染 |
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| Research Abstract |
Heat-killed Candida albicans (HKCA) and water-soluble mannoprotein-β-glucan complex from C. albicans (CAWS) did not up-regulate adhesion of Porphyromonas gingivalis to human gingival epithelial cells and gingival fibroblasts and expression of β1 integrin and ICAM-1, which are required for P.gingivalis invasion, on the cells. However, HKCA and CAWS promoted invasion of human gingival epithelial cells and gingival fibroblasts by P.gingivalis.
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