2011 Fiscal Year Final Research Report
The roles of Wnt/β-catenin signaling on differentiation of mesenchymal progenitor cells.
| Project/Area Number |
21791799
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
NAITO Masako 日本大学, 歯学部, 助教 (40436803)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 間葉系前駆細胞 / 脂肪細胞 / 骨芽細胞 / 分化 |
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| Research Abstract |
In this study, we examined the expression and activity of Wnt/β-catenin signaling pathway molecules in mesenchymal progenitor cells(ROB-C26). Immunocytochemical analysis and gene-silencing experiments revealed that the inhibition of β-catenin expression by Dex promotes the differentiation of mesenchymal progenitor cells into adipocytes.
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