2010 Fiscal Year Final Research Report
Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodor
| Project/Area Number |
21791810
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
KEZUKA Yuichiro Iwate Medical University, 薬学部, 助教 (50397163)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔生化学 |
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| Research Abstract |
In this study, I focused on oral bacteria that highly produce hydrogen sulfide, a causative agent of oral malodor, and determined the structure of hydrogen sulfide-producing enzymes and their complex with a substrate analogue. We also succeeded to trap reaction intermediates. On the basis of structural information and/or enzymological data, conformational changes of enzyme during reaction and roles of amino acid residues at the active site were revealed. These results are quite important to descript their enzymatic reaction mechanisms and are expected to lead the search for novel prophylactic drugs that prevent oral malodor.
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[Journal Article] Production of hydrogen sulfide by two enzymes associated with biosynthesis of homocysteine and lanthionine2010
Author(s)
Yoshida, Y., Ito S., Kamo, M., Kezuka, Y., Tamura, H., Kunimatsu, K., Kato, H.
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Journal Title
Fusobacterium nucleatum subsp. nucleatum ATCC 25586. Microbiology 156
Pages: 2260-2269
Peer Reviewed
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[Remarks] ホームページ等
