2010 Fiscal Year Final Research Report
Molecular mechanisms of resistance to interferon-gamma in human oral squamous carcinoma.
| Project/Area Number |
21791812
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
SEKINE Keisuke Yokohama City University, 医学部, 助教 (00323569)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔生化学 |
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| Research Abstract |
In this study, I examined the molecular mechanisms underlying the IFN-gamma dependent cell cycle arrest observed in human oral squamous cell carcinoma. I have previously revealed that IFN-gamma induced Rb activation results in cell cycle arrest. First, it is revealed that STAT1, a signal transducer of IFN-gamma mediate IFN-gamma dependent Rb activation. Second, it is revealed that there are several molecules that is up-regulated through IFN-gamma stimuli and which is observed up-stream of Rb activation.
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Research Products
(9 results)
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[Journal Article] Multiple Biological Complex of Alkaline Extract of the Leaves of Sasa senanensis Rehder.2010
Author(s)
Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.
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Journal Title
In Vivo 24
Pages: 735-743
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