2010 Fiscal Year Final Research Report
To clarify the role of osteoclast fusion in bone homeostasis
| Project/Area Number |
21791813
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Keio University |
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Principal Investigator |
IWASAKI Ryoutarou Keio University, 医学部, 助教 (30365390)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯学 / 発生・分化 / 遺伝子 |
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| Research Abstract |
We generated a DC-STAMP transgenic mice and analysed it. We find out a Inhibition of DC-STAMP provides both decreased osteoclast activity and increased bone formation by osteoblasts, thereby increasing bone mass in an un-coupled and a tissue specific manner.
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Research Products
(5 results)
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[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010
Author(s)
Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.
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Journal Title
J Exp Med. 207(4)
Pages: 751-762
Peer Reviewed
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[Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner.2009
Author(s)
Miyamoto K, Ninomiya K, Sonoda KH, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egashira K, Suda T, Toyama Y, Miyamoto T.
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Journal Title
Biochem Biophys Res Commun. 383(3)
Pages: 373-377
Peer Reviewed
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