Analysis of the pre-motorneurons in the suckling rhythm generating network using a neonatal mouse brainstem-spinal cord preparation.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791814
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Showa University
• Principal Investigator: NAKAYAMA Kiyomi Showa University, 歯学部, 助教 (00433798)
• Project Period (FY): 2009 – 2010
• Keywords: 吸啜 / 神経回路 / リズム形成 / マウス

Research Abstract

Suckling movements play an important role to acquire the energy for living in the mammalians during postnatal period. The suckling movements are rhythmic movement evoked by tactile stimulation of the lip or the oral mucosa. It is known that the suckling rhythm is generated in neuronal networks in the brainstem, but kinds of interneurons involved in the neuronal networks are unclear. In the present study, we analyzed interneurons involved in the suckling rhythm generator using an isolated brainstem preparation from neonatal mice.

Research Products

• [Journal Article] Decreased intake of sucrose solutions in orexin knockout mice. (2011)
  • Author(s): Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.
  • Journal Title: J.Mol.Neurosci. 43 Pages: 217-224
  • Peer Reviewed
• [Journal Article] Properties of synaptic transmission from the reticular formation dorsal to the facial nucleus to trigeminal motoneurons during early postnatal development in rats. (2010)
  • Author(s): Gemba-Nishimura A, Inoue T, Nakamura S, Nakayama K, Mochizuki A, Shintani S, Yoshimura S.
  • Journal Title: Neuroscience 166 Pages: 1008-1022
  • Peer Reviewed
• [Presentation] Neuronal mechanisms generating electrical stimulation-evoked rhythmic burst activity in the trigeminal nerve of eonatal mice. (2011)
  • Author(s): Nakayama K, Ihara Y, Inoue T.
  • Organizer: Society for Neuroscience 40th annual meeting
  • Place of Presentation: San Diego
  • Year and Date: 20111113-20111117
• [Presentation] 新生マウス脳幹摘出標本におけるリズミックな顎運動の誘発 (2010)
  • Author(s): 中山希世美、望月文子、西村晶子、井上富雄
  • Organizer: 日本顎口腔機能学会 第45回学術大会
  • Place of Presentation: 埼玉
  • Year and Date: 20101106-20101107
• [Presentation] 新生マウス脳幹摘出標本における三叉神経刺激誘発リズムに関与する神経伝達物質 (2010)
  • Author(s): 中山希世美、伊原良明、井上富雄
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 20100902-20100904
• [Presentation] 三叉神経中脳路核ニューロンにおけるオレキシンの作用 (2010)
  • Author(s): 中山希世美、望月文子、井上富雄
  • Organizer: 第7回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 20100511-20110512
• [Presentation] 新生マウス脳幹摘出標本における三叉神経刺激による顎運動の誘発 (2009)
  • Author(s): 中山希世美、伊原良明、井上富雄
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20090916-20090918
• [Presentation] 新生マウス脳幹摘出標本において三叉神経の電気刺激により誘発される顎運動 (2009)
  • Author(s): 中山希世美、伊原良明、井上富雄
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 20090910-20090911
• [Presentation] オレキシンの三叉神経中脳路核ニューロン活動に対する影響 (2009)
  • Author(s): 井上富雄、望月文子、中山希世美
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 20090910-20090911
• [Presentation] Effects of orexin on activities of mesencephalic trigeminal sensory neurons in developing rats. (2009)
  • Author(s): Inoue T, Nakayama K, Mochizuki A, Nakamura S, Shioda S.
  • Organizer: Society for Neuroscience 39th annual meeting
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-17
• [Presentation] Rhythmic motor activity evoked by electrical stimulation of the trigeminal nerve sensory root in neonatal mice.
  • Author(s): Nakayama K, Ihara Y, Inoue T.
  • Organizer: 第88回日本生理学会 第116回日本解剖学会総会・全国学術集会 合同大会、会場での開催中止により誌上開催
• [Presentation] Left and right coordination of NMDA-induced rhythmic activities in the trigeminal nerves of neonatal mice in vitro.
  • Author(s): Ihara Y, Nakayama K, Inoue T.
  • Organizer: 第88回日本生理学会 第116回日本解剖学会総会・全国学術集会 合同大会、会場での開催中止により誌上開催