2010 Fiscal Year Final Research Report
Elucidation of regulatory mechanism of bone metabolism by Wnts secreted from osteoclasts.
| Project/Area Number |
21791818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
UEHARA Shunsuke Matsumoto Dental University, 歯学部, 助教 (90434480)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 破骨細胞 / 骨芽細胞 / Wnt / カップリング / 細胞間情報伝達 |
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| Research Abstract |
Bone is remodeled by osteoclastic bone resorption and osteoblastic bone formation. I hypothesized that some Wnts were involved in coupling between osteoblasts and osteoclasts. At first, I tried to demonstrate an Wnt secreted from osteoclasts stimulate bone formation activity of osteoblasts. But this trial was false. Second, I analyzed expression level of Wnt related genes in tibia from mice. I revealed that expression level of some Wnt related genes were changed age-dependently.
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