Analysis of p53-independent tumor surveillance.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791823
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Hiroshima University
• Principal Investigator: TOBIUME Kei Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 (40350037)
• Project Period (FY): 2009 – 2010
• Keywords: がん / アポトーシス

Research Abstract

To identify the apoptosis-regulating machinery in p53-defective cancer cell would benefit the better strategy for cancer treatment. Present study revealed bim-dependent apoptotic pathway could survey to eliminate p63-downlagurated dangerous cancer cells. The harmful activation of EMT-inducing factor snail was also monitored by the concomitant cellular p63 downregulation, however, snail could provoke another pathway to evade bim-mediated apoptosis, which suggested the acquisition of higher invasiveness requires second round of evasions both from p53-dependent and p53-independent tumor surveillances.

Research Products

• [Journal Article] PGE2 targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction. (2011)
  • Author(s): Shigeishi H, Higashikawa K, Hatano H, Okui G, Tanaka F, Tran TT, Rizqiawan A, Ono S, Tobiume K, Kamata N
  • Journal Title: Cancer letters in press
  • Peer Reviewed
• [Journal Article] RHAMM ERK interaction induces proliferative activities of cementifying fibroma cells through a mechanism based on the CD44-EGFR. (2011)
  • Author(s): Hatano H, Shigeishi H, Kudo Y, Higashikawa K, Tobiume K, Takata T, Kamata N
  • Journal Title: Lab Invest 91 Pages: 379-391
  • Peer Reviewed
• [Journal Article] Delta N p63 alpha dependent expression of Id3 distinctively suppresses the invasiveness of human squamous cell carcinoma with epithelial to mesencymal transition (2009)
  • Author(s): Higashikawa K, Yoneda S, Tobiume K, Saitoh M, Taki M, Mitani Y, Shigeishi H, Ono S, Kamata N
  • Journal Title: Int J Cancer 124 Pages: 2837-2844
  • Peer Reviewed
• [Presentation] Paracrine PGE2 targets epiregulin over expressing squamous cell carcinoma for resistance to anti-5-FU-induced apoptosis (2010)
  • Author(s): Higashikawa K, Shigeishi H, Tobiume K, Hatano H, Tanaka F, Okui G, Ono S, Kamata N
  • Organizer: 第69回日本癌学会・学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] A snail target gene product Cyr61 regulates the invasiveness of squamous cell carcinoma (2010)
  • Author(s): Tanaka F, Higashikawa K, Tobiume K, Ono S, Shigeishi H, Kamata N
  • Organizer: 第69回日本癌学会・学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] PGE2-induced expression of NR4A2 confers anti-apototic capability. (2010)
  • Author(s): Shigeishi H, Higashikawa K, Hatano H, Tobiume K, Kamata N
  • Organizer: 88^<th> General Session and Exhibition of the IADR
  • Place of Presentation: Spain
  • Year and Date: 2010-07-16
• [Presentation] A Snail induced secretory protein associated with the invasiveness of squamas cell carcinoma. (2009)
  • Author(s): Tanaka F, Higashikawa K, Tobiume K, Ono S, Shigeishi H, Kamata N
  • Organizer: 第68回日本癌学会・学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Functional Analysis of Snail-mediated downregulation of deltaNp63alpha in squamous cell carcinoma (2009)
  • Author(s): Higashikawa K, Tobiume K, Kamata N
  • Organizer: 第68回日本癌学会・学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03