2010 Fiscal Year Final Research Report
Tri-functional antibody to OSCC and complement regulatory proteins
| Project/Area Number |
21791828
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagoya City University |
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Principal Investigator |
IMAI Masaki Nagoya City University, 大学院・医学研究科, 講師 (30440936)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔癌 / 抗体 / 免疫療法 |
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| Research Abstract |
We have studied the anti-tumor activities of an anti-MUC1 antibody with oral squamous cell carcinoma (OSCC). We hypothesized the inhibition of complement regulatory proteins (CRPs) could enhance anti-tumor activity. Therefore, that reversing the effects of complement regulatory proteins expressed on a tumor cell surface will allow more effective immune-mediated clearance of tumor cells and improve prospects for successful immunotherapy. When the complement-dependent cytotoxicity was compared treatment with both an anti-MUC1 mAb and inhibiting mAbs of CD55 or CD59 to an anti-MUC1 mAb alone, a 2- to 3-fold increase in C-dependent cell lysis was observed, respectively. It was also proposed to produce the tri-functional antibodies recognized both MUC1 and CRPs. We done to produce the expression vectors of tri-functional antibodies.
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Research Products
(11 results)
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[Journal Article] Endothelin receptor antagonist attenuates inflammatory response and prolongs the survival time in a neonatal sepsis model.2010
Author(s)
Goto T, Hussein MH, Kato S, Daoud GA, Kato T, Sugiura T, Kakita H, Nobata M, Mizuno H, Imai M, Ito T, Kato I, Suzuki S, Okada N, Togari H, Okada H
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Journal Title
Intens Care Med. 36(12)
Pages: 2132-2139
Peer Reviewed
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[Journal Article] Connective tissue growth factor (CTGF/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate.2010
Author(s)
Mizutani M, Ito Y, Mizuno M, Nishimura H, Suzuki Y, Hattori R, Matsukawa Y, Imai M, Oliver N, Goldschmeding R, Aten J, Krediet RT, Yuzawa Y, Matsuo S
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Journal Title
Am J Physiol Renal Physiol. 298
Pages: F721-733
Peer Reviewed
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[Presentation] An acetylated anti-C5a complementary peptide reduced cytokines and free radicals and prolongs survival time in a neonatal sepsis model.2009
Author(s)
Hussein MH, Kato S, Goto T, Daoud GAH, Kato I, Suzuki S, Togari H, Hashimoto T, Imai M, Okada N, Okada H.
Organizer
12th European Meeting on Complement in Human Disease
Place of Presentation
Visegrad, Hungary
Year and Date
20090905-20090908
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