2011 Fiscal Year Final Research Report
Continual Gram-negative bacterial challenge accelerates stroke onset SHRSP rats
| Project/Area Number |
21791832
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳卒中 / 歯周病 / 慢性感染症 / 酸化ストレス / 食塩 / 高脂肪食 |
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| Research Abstract |
This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in Stroke-prone spontaneously hypertensive rats(SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides, as compared to uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in lipopolysaccharide-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, TBARS, and 8-OHdG increased in lipopolysaccharide-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from lipopolysaccharides.
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