2010 Fiscal Year Final Research Report
Analysis for the mechanisms of NK cell invasion into the connective tissue which is elucidate for mechanism of inflammation
| Project/Area Number |
21791833
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Osaka Dental University |
|---|
Principal Investigator |
INOUE Hiroshi Osaka Dental University, 歯学部, 講師 (10330143)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | NK細胞 / MMP / ケモカイン |
|---|
| Research Abstract |
Natural killer (NK) cells play a key role in inflammation and tumor regression through their ability to migrate into tissues. CXCL12 is a chemokine that promotes lymphocyte invasion and migration into tissues. However, the mechanism for this process remains incompletely understood. In this study, we show that CXCL12 significantly enhanced NK cell invasion into type I collagen and increase the production of matrix metalloproteinase- 1 (MMP-1). Confocal immunofluorescence studies show that MMP-1 colocalized on NK cell surface that was stimulated by CXCL12.
|
