2010 Fiscal Year Final Research Report
Nuerophysical analysis about nausea and vomiting-Function of hyperpolarization activated cation channel-
| Project/Area Number |
21791896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KODAMA Naoki Okayama University, 大学院・医歯薬学総合研究科, 助教 (70534519)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 延髄最後野 / 過分極作動性カチオンチャネル / 塩酸セビメリン / 嘔吐 / パッチクランプ法 / ラット |
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| Research Abstract |
Hyperpolarization-activated cation channel (Ih channel) acts as the pacemaker in the central nervous system, and the functional role of Ih channel in the area postrema (AP) has not been fully understood. So the aim of this study was to elucidate the electrophysiological role of Ih channel, the activation for cevimeline in AP and the mechanism of nausea and vomiting. This study suggests that AP neurons may contribute to the cevimeline-induced nausea and vomiting.
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Research Products
(15 results)
