2011 Fiscal Year Final Research Report
The role of DCs in Ni allergy development in the mouse model
| Project/Area Number |
21791901
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
WATANABE Megumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40380050)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 金属アレルギー / 樹状細胞 / MAPキナーゼ / ニッケル |
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| Research Abstract |
We have analyzed Ni allergy symptoms in focus on dendritic cells in the mouse model we produced. In this study, we regulated MKK6 expression and activation to regulate Ni allergy symptoms in our mouse model. In addition, we found activation of RhoA after the stimulation with Ni. From these data, it may be possible to control Ni allergy by regulation of small G-protein in dendritic cells.
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