Basic study for development of osteogenic differentiation potential determination kit of mesenchymal stem cells

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791939
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nagasaki University (2010); Hiroshima University (2009)
• Principal Investigator: SUEHIRO Fumio Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (40524781)
• Project Period (FY): 2009 – 2010
• Keywords: 再生医療 / 幹細胞 / 骨再生 / 遺伝子 / 細胞移植

Research Abstract

I had identified eleven novel transcription factors that involves in human Mesenchymal stem cells (MSC) osteogenesis. Interaction of these factors might progress MSC osteogenic differentiation. Especially, factors which suppress osteogenic differentiation might show negative feedback toward osteogenic differentiation. Clinical application of these transcription factors, especially two factors, might be used for prognostic marker for osteogenic potential of MSC and may be useful for quality check before MSC transplantation in the future medicine.

Research Products

• [Journal Article] Impact of Zinc Fingers and Homeoboxes 3(ZHX3) on the Regulation of Mesenchymal Stem Cell Osteogenic Differentiation.
  • Author(s): Suehiro F., Nishimura M., Yoshizawa Y., Kawamoto T., Kanawa M., Murata H., Kato Y.
  • Journal Title: Stem cells and Development in press
  • Peer Reviewed
• [Presentation] Novel osteogenic specific transcription factors on mesenchymal stem cells (MSC) for alveolar ridge augmentation. (2011)
  • Author(s): Suehiro F.
  • Organizer: 3rd International Workshop on BioDental Education & Research Hiroshima University Graduate School of Biomedical Sciences 2011
  • Place of Presentation: Hiroshima.
  • Year and Date: 20110128-20110130
• [Presentation] 間葉系幹細胞における骨分化特異的転写因子の解析 (2010)
  • Author(s): 末廣史雄
  • Organizer: 第40回日本口腔インプラント学会学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-18
• [Presentation] 間葉系幹細胞の骨分化に関わる新規転写因子ZHX3の機能解析 (2010)
  • Author(s): 末廣史雄
  • Organizer: 第9回日本再生医療学会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-19
• [Book] Interface Oral Health Science 2009 Interface, implant, regenerated bone and recipient alveolar bone. (2010)
  • Author(s): Nishimura M., Sakai Y., Suehiro F., Tsuboi M., Kamada K., Hori T., Sakai M., Takeda M., Tsuji K., Hamada T.
  • Total Pages: 119-122