Development of implant inducing antimicrobial protein production

2010 Fiscal Year Final Research Report

• Project/Area Number: 21791947
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: KUSANO Kaoru Health Sciences University of Hokkaido, 歯学部, 助教 (80382498)
• Project Period (FY): 2009 – 2010
• Keywords: 歯科インプラント / インプラント表面 / ディフェンシン / インプラント周囲炎

Research Abstract

This study investigated the influence of surface topographies on cell shape, proliferation, and human beta-defensin (HBD) expression of the tissues surrounding the implants for clinically-applied dental implants with four different surface topographies : mechanically polished (PO), coarse sand blasted (B), acid etched (AE), and sandblasted and acid etched (SLA), and micro gap-cornered-box (MGCB) surface topography.

Research Products

• [Journal Article] Microtopographical regulation of adult bone marrow progenitor cells chondrogenic and osteogenic gene and protein expressions. (2010)
  • Author(s): Yang Y, Kusano K, Frei H, Rossi F, Brunette DM, Putnins EE.
  • Journal Title: J Biomed Mater Res A 95(1) Pages: 294-304
  • Peer Reviewed
• [Journal Article] The effect of surface topography on early NFkB signaling in macrophages. (2010)
  • Author(s): Waterfield JD, Ali TA, Nahid F, Kusano K, Brunette DM.
  • Journal Title: J Biomed Mater Res A 95(3) Pages: 837-47
  • Peer Reviewed
• [Presentation] Eff ects of Gap-Cornered-box Topographies on BM-MSC and Osteoblast Prolifera tion. (2010)
  • Author(s): Kusano K, Yang Y, Ghrebi S, Kusu hara F, Putnins EE,Brunette DM.
  • Organizer: 88^<th> International Association for Dental Research.
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2010-07-17
• [Remarks] ホームページ等