2010 Fiscal Year Final Research Report

Functionalization of the immediate loading implant by nano-materials and artificial proteins

Research Project

Project/Area Number	21791959
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Tokyo Dental College (2010) Japanese Foundation For Cancer Research (2009)
Principal Investigator	KOKUBUN Katsutoshi Tokyo Dental College, 歯学部, 助教 (90535808)
Project Period (FY)	2009 – 2010
Keywords	歯学 / インプラント / チタン / ナノ材料 / 人工タンパク質 / 表面改質 / DDS
Research Abstract	Modification of the surfaces of materials, such as titanium, is important in the medical engineering area. We are employing our "carbon nanomaterials" and "motif-programmed artificial proteins" methodology in order to biologically modify the surface of titanium. We have demonstrated that DEX (Dexamethasone)-CNH on titanium attractive candidates four use in a novel drug delivery system. DEX-CNH exhibited sustained release of biologically active DEX in mammalian cells without significant side effects. Furthermore, we successfully created artificial proteins that contain embedding cell attachment and Ti-binding motifs and endowed Ti with cell attachment activity.