2011 Fiscal Year Final Research Report
The judgment of oral carcinoma which shows tolerance to the chemotherapy by miRNA in serum.
| Project/Area Number |
21791960
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
MATSUDA Aya 北海道大学, 大学院・歯学研究科, 学術研究員 (60514312)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床腫瘍学 |
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| Research Abstract |
The cisplatin resistant cell and the cisplatin sensitive cell were established from the oral carcinoma cell line. The genes which participate in cisplatin tolerance using these cells, and miRNAs combined with the genes were searched. It was suggested that the expression patterns of miRNA change cisplatin resistant, and miRNA in blood is participating in malignancy of oral carcinoma.
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[Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment2012
Author(s)
Akiyama K, Ohga N, Hida Y, Kawamoto T, SadamotoY, Ishikawa S, Akino T, Kondoh M, Maishi N, Matsuda A, Inoue N, Shindoh M, Hida K.
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Journal Title
Am J Pathol
Volume: 180
Pages: 1283-93
Peer Reviewed
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